Nevertheless, in vitro experiments with human platelets point out that sildenafil potentiates the antiaggregatory impact of sodium nitroprusside (a nitric oxide donor). Furthermore, The mixture of heparin and VIAGRA had an additive impact on bleeding time in the anesthetized rabbit, but this interaction hasn't been examined in humans.
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Outcomes of Other Drugs on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (main route) and CYP2C9 (small route). Therefore, inhibitors of these isoenzymes may perhaps reduce sildenafil clearance and inducers of such isoenzymes may well increase sildenafil clearance.
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The examples and perspective in this section offer principally with the United States and don't stand for a worldwide watch of the subject.
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